Sema3E-plexinD1 Axis Is a Modulator of Foxp3<sup>+</sup> Regulatory T-Cells in House Dust Mite Model of Asthma.

Lastly, although H&E staining of lung tissue sections revealed an increasing trend in severity of inflammation in Foxp3 PLXND1 KO mice compared to the PLXND1 fl/fl the result did not reach statistical significance (Figure 4G,H ).

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Our findings demonstrate that the reduction in Foxp3 + Tregs in Foxp3 PLXND1 KO mice was accompanied by fewer IL‐4‐producing CD4+ T cells in the spleen and a decreasing trend of IL‐4 levels in BALF, suggesting a potential mechanistic link between plexinD1 signaling and IL‐4–mediated Treg stability.

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