Combined inhibition of de novo pyrimidine synthesis and ATR promotes ATF4-mediated cell death in <i>TP53</i>-deficient ALL.

In the Nalm6 TP53 KO ATF4 KD models, we found a significant decrease in DDIT3 expression in both shATF4‐1 and shATF4‐2 knockdown models compared to the shScrambled control, as well as a decreasing trend in TRIB3 expression (Figure 2E ).

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