Astrocyte store-operated calcium entry is required for centrally mediated neuropathic pain.

2 , 5 , 28 , 34 , 39 Our major finding that astrocyte SOCE is essential for CS is highly significant in this regard, because SOCE produces microdomain Ca 2+ signals that can activate downstream signaling processes independently of Ca 2+ that is released by IP 3 Rs. 10 , 30 It is likely that SOCE in astrocytes is activated subsequent to IP 3 R-mediated ER Ca 2+ release, and the combination of IP 3 R-mediated somatic Ca 2+ signals and SOCE-mediated microdomain Ca 2+ signals may provide a robust, multifaceted Ca 2+ signaling paradigm that results in highly efficient and specific activation of astrocyte functions to drive CS.

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