Blood multiomics reveal a dysregulated lipid mediator-mitochondrial network associated with the outcome of advanced cirrhosis.

As expected, in our multiomics study, disease severity followed an increasing trend from SDC to UDC peaking at the pre-ACLF group, whose patients had higher rate of ascites and infections, higher serum bilirubin, INR, creatinine, ALT, leukocyte and neutrophil counts, and CRP, and lower hematocrit, mean arterial pressure, and serum levels of sodium and albumin (Supplementary Table 1 ).

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