A frameshift variant in FAM129C contributes to achalasia through B cell responses against the GABA<sub>A</sub> receptor.

Nat Commun · 2026 · PMC13385689 · PMID 42185265

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an increasing trendno p-value reported

Bulk RNA-seq analysis of LES showed that the expression of Cd79a, Cd19 and other immunoglobulin-related proteins exhibited an increasing trend in Fam129c -mut mice compared to WT controls (Fig. 3A ).

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A frameshift variant in FAM129C contributes to achalasia through B cell responses against the GABA&lt;sub&gt;A&lt;/sub&gt; receptor.

The sentences

A frameshift variant in FAM129C contributes to achalasia through B cell responses against the GABA<sub>A</sub> receptor.