Gender differences in the plasma profiles of proprotein convertase subtilisin/kexin-type 9 (PCSK9), soluble low-density lipoprotein receptor (sLDLR), total cholesterol, and triglycerides in patients with colorectal cancer liver metastases: diagnostic and prognostic implications.

Given that these patients exhibited the most pronounced alterations in PCSK9 and sLDLR levels, the correlation of the PCSK9/sLDLR ratio with the presence of ≥ 5-cm metastases was also examined, revealing a highly significant correlation ( r = 0.4527, P = 0.0006), and difference of this ratio between patients without and with ≥ 5-cm metastases (3.21 ± 1.41 vs . 1.68 ± 0.62, P = 0.0006, Fig. 2 D).

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