<i>16p11.2</i> microdeletion enhances gene expression variability between human IPSC-derived forebrain interneuron progenitor cells in culture.

CON samples revealed a highly significant global difference in EVA values between CON and DEL progenitors ( n = 94 regulons, 3 sample of each genotype paired t-test p = 5.94×10 -25 ) with EVA( DEL-CON ) values showing a strong bias toward positive values ( Figure 4A ) indicating increased global gene expression variability in DEL compared to CON progenitor populations even in unrelated sets of genes.

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