Maternal control during prenatal oxycodone exposure: differential effects of voluntary versus involuntary self-administration on offspring substance use vulnerability in rats.

Neuropsychopharmacology · 2026 · PMC13389499 · PMID 42082774

Europe PMC DOI

hedged sentence

0.0550

closest p · 1.1× alpha

0.0550

boldest claim

The sentences

a trend toward significancep = 0.055so close (0.05 < p ≤ 0.1)

This effect reached significance by session 6 ( p < 0.05 as compared to Saline-Yoked) and by the final FR1 session, female offspring of Oxycodone-Yoked dams had higher active lever pressing compared to Saline-Yoked offspring ( p < 0.001), and there was a trend toward significance when compared to Oxycodone-Lead female offspring ( p = 0.055).

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