Systemic immune remodeling following curative (R0) resection of colorectal liver metastases.

Front Immunol · 2026 · PMC13391566 · PMID 42495608

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a decreasing trendno p-value reported

Additionally, a decreasing trend in the frequencyxof PD-1+ TIM3+ double-positive cells was observed in both CD4+ and CD8+ T-cell subsets after liver resection ( Supplementary Figure 5 ).

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an increasing trendno p-value reported

Moreover, CD68+ TIM3+ double-positive macrophages at the tumor-liver interface of CRLM exhibited an increasing trend in KRAS-mutated tumors compared with KRAS-wild-type tumors (mean percentage: 22.52% vs. 8.84%) ( Supplementary Figure 8C ).

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