Sex-dependent Schizophrenia and Drug Reward Behavioral Phenotypes in Metabotropic Glutamate 5 Receptor Heterozygous and Homozygous Mice.

For the conditioned place preference data, we compared effect sizes using 90% confidence intervals to ascertain if cocaine memory was stronger in mGlu5 HOMO or mGlu5 HET than WT, as all genotypes showed highly significant P -values (all P ’s < .001) and large effect sizes (all η 2 > .14). 62 Exclusions: 1 WT male was excluded from the OF as the equipment stopped working 20 min into the test. 2 mice were excluded from the NORT analysis because they spent <10 s total time nosing both objects (1x WT male, 1x mGlu5 HOMO male). 1 mGlu5 HOMO male was excluded as an outlier from PPI because the acoustic startle response was >2 standard deviations from the mean.

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