Preformed fibrils of α-synuclein rapidly activate LRRK2 on early endosomes, driving Rab5 phosphorylation and disrupting endolysosomal and synaptic function.

NPJ Parkinsons Dis · 2026 · PMC13392030 · PMID 42120407

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highly significantno p-value reported

At 2 h, the increases were highly significant (6.2-fold for LRRK2, 1.7-fold for Rab5, 3.0-fold for Rabex-5, and 3.3-fold for Rabaptin-5).

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