The key role of RANKL and OPG as molecular biomarkers in bone remodeling associated with different grafts regarding socket preservation: A systematic review.

J Taibah Univ Med Sci · 2026 · PMC13392943 · PMID 42494999

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highly significantp = 0.001actually significant

Calcium carbonate (CaCO 3 ) derived from pearl oyster shells was evaluated and the study reported progressive RANKL suppression from 8.00 ± 1.00 on day 7 to 2.67 ± 1.53 on day 21 ( Table 2 ) in the study group, with a highly significant difference ( p = 0.001, Table 4 ). 27 Compared with the negative control group, the fold change in RANKL decreased to 4.75× on day 21.

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