A Blood-Derived Factor Rescues ALS: Platelet Factor 4 Activates OPTN-Dependent Autophagy to Clear SOD1 Aggregates Independently of PINK1.

This unbiased profiling revealed highly significant differential expression in specific targets—notably Lrp1, Gpc1, Sdc1, and Tlr4—providing a data‐driven rationale to focus on LRP1 (Figure 13A and Figure S8 ).

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