highly significantp = 0.003
After Holm correction for multiple comparisons, the between-group difference at the immediate postoperative time point (CrH0) reached nominal significance (adjusted p = 0.030), whereas differences at 24, 48, and 72 h were highly significant (CrH24: adjusted p = 0.003; CrH48: adjusted p = 0.002; CrH72: adjusted p = 0.002), suggesting that the divergence between MHR groups became more pronounced and sustained from 24 h onward.