Barely Significant
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Perampanel as add-on in high-grade glioma-related epilepsy: Seizure control and QoL in a prospective, multicenter, real-world 6-month follow-up study.

Epilepsia Open · 2026 · PMC13394621 · PMID 42237784

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a trend toward significanceno p-value reported
Covariates included in the final Cox model were selected through a two‐step process: (i) exploratory Cox models grouping demographic, tumor‐related, and epilepsy‐related variables were first tested independently; (ii) variables showing a trend toward significance or strong clinical plausibility were retained in order to avoid overfitting while preserving control for potential confounders.

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