Association of four non-insulin-based insulin resistance surrogate markers with colorectal cancer risk: a large-scale prospective cohort study using the UK Biobank.

Front Endocrinol (Lausanne) · 2026 · PMC13395652 · PMID 42500127

Europe PMC DOI

hedged sentence

0.0010

closest p · 0.0× alpha

0.0010

boldest claim

The sentences

highly significantP < 0.001actually significant

Consistent with these findings, our evaluation of clinical incremental value demonstrated highly significant improvements in global model fit upon adding these IR indices (LRT P < 0.001), with METS-IR providing the highest incremental utility.

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