The FEV 1 /FVC ratio followed the same pattern, showing a significant reduction in severe cases compared to mild and moderate asthma ( p < 0.0001), with no significant genotypic variation.FEV 1 reversibility, a key marker of bronchodilator response, also exhibited a decreasing trend with increasing severity, which aligns with the expected pathophysiology of β 2 agonist refractory asthma.
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Lack of association between ADRB2 (Gln27Glu) variant with susceptibility, severity and salbutamol response in South Indian asthmatics.
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