Assessment of genetic susceptibility in patients with oral squamous cell carcinoma: a systematic review and meta-analysis.

Commun Med (Lond) · 2026 · PMC13396505 · PMID 41862530

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highly significantno p-value reported

The subgroup analysis shows polymorphism in P53 gene in presence of smoking ( Z = 2.15, p = 0.02), alcohol ( Z = 2.38, p = 0.02) and mixed habit (tobacco + alcohol) ( Z = 3.28, p ≤ 0.001) and CASP 8 ( Z = 5.38, p ≤ 0.0001) in presence of alcohol consumption habit has highly significant risk for development of OSCC; however the studies shows moderate heterogeneity ( I 2 = 40–50%).

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