Microglial CD31 suppresses Aβ clearance and promotes Alzheimer pathology in 5×FAD mice.

Nat Commun · 2026 · PMC13396677 · PMID 42248891

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Compared with 5×FAD-WT mice, hippocampal tissues from CD31-knockdown mice showed significantly increased levels of IL-10 and CD206, accompanied by a decreasing trend in pro-inflammatory markers IL-1β, IL-6, and CD80 (Fig. 2G, H ). qPCR analysis further confirmed a significant upregulation of IL-10 and downregulation of IL-6 and TNF-α (Fig. 2I ).

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