Association between Salivary Cortisol, Secretory IgA, and Inflammatory Cytokines with Early Childhood Caries: A Cross-sectional Analytical Study.

J Int Soc Prev Community Dent · 2026 · PMC13397212 · PMID 42500375

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a decreasing trendno p-value reported

The findings demonstrated significantly elevated levels of cortisol, IL-6, IL-1β, and TNF-α in children with ECC compared to controls, whereas sIgA showed a decreasing trend, supporting the hypothesis that ECC involves complex interactions between stress physiology, immunity, and inflammatory processes.

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