Cholinergic Modulation of Proteinoid Microsphere Networks as Prebiotic Depression Models.

This creates a “shunting inhibition” effect: the leaky membrane creates a low-resistance path that prevents the accumulation of charge necessary for threshold depolarization. Statistical analysis ( Figure ) confirms that while peak current magnitude shows high variance ( p = 0.110), the increase in hysteresis energy is highly significant ( p < 0.001).

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