The Bunyamwera orthobunyavirus Gc glycoprotein head and stalk drives an infectious virion assembly pathway specific for the insect host.

There was a slight reduction in rBUNV-∆tripod titre, in both cell lines, when compared to rBUNV-WT but again this was not as significant a reduction as rBUNV-∆7 in C6/36 cells, suggesting the alanine substitutions introduced in an attempt to disrupt Gc head trimerisation do not account for the reduced rBUNV-∆7 viability is reduced in C6/36 cells. ∆7-Gc is transported to the plasma membrane in insect cells To investigate whether Gc l

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