Influence of Fractionation and Beam Sequencing on Absorbed Dose to Circulating Lymphocytes During Ultra-High Dose Rate and Conventional Radiotherapy: An In Silico Study.

JCO Clin Cancer Inform · 2026 · PMC13399734 · PMID 42467876

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highly significantp < 1.39 × 10 − 6actually significant

Overall paired comparisons across the five irradiation scenarios demonstrated highly significant differences for both the mean blood dose and the mean circulating lymphocyte dose (Friedman test: χ 2 = 646.4 , p < 1.39 × 10 − 6 and χ 2 = 638.8 , p < 6.30 × 10 − 6 , respectively) (Data Supplement).

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