Mechanisms of Differential Signal Transduction by Interferon Lambda Receptor 1 Variants.

J Innate Immun · 2026 · PMC13399965 · PMID 42213608

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an unexpected trendno p-value reported

Both variants in dox-uninduced WT iHeps enabled increased pJAK1 and pTYK2 relative to EV control iHeps, with an unexpected trend toward greater pJAK1 and pTYK2 in FLAG-Iso2 cells ( Fig. 3 a, b; online suppl.

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a nonsignificant trendno p-value reported

Similarly, both variants supported increased pSTAT1 and pSTAT2 relative to EV control iHeps, with a nonsignificant trend toward lower pSTAT1 and significantly less pSTAT2 in FLAG-Iso2 cells ( p ≤ 0.05, Fig. 3 a, b; online suppl.

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