Exosomes delivering a high-throughput-screened RNA polymerase inhibitor for highly effective therapy of multidrug-resistant bacterial infected pneumonia.

Bioact Mater · 2026 · PMC13400349 · PMID 42502321

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a decreasing trendno p-value reported

After co-culturing compound EPI and bacteria respectively, the ATP metabolism level of bacteria showed a decreasing trend with the increase of EPI concentration, which means that the ATP activity decreased with the increase of the concentration of the drug used, and thus compound EPI has a certain inhibitory effect on bacterial ATP ( Fig. 3 B).

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