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In vivo assessment of collagen transdermal absorption in murine and human skin using photoacoustics microscopy.

Sci Rep · 2026 · PMC13402328 · PMID 42168543

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a decreasing trendno p-value reported
Notably, while free ICG and ICG-P groups showed a decreasing trend over time in ventral skin, the ICG-C3 group maintained relatively constant signals throughout the 10-minute observation window (Fig. 3 D), suggesting its potential to prolong retention in the dermal layer by mitigating rapid clearance mechanisms.

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