Plasma ApoE proteotyping for ApoE ε4 stratification in the anti-amyloid therapies era.

The ApoE ratio showed distinct genotype-dependent distributions with a highly significant overall group effect ( p < 0.001) and showed separation across genotype groups in this cohort, with no observed overlap between ε4 non-carriers, heterozygotes, and homozygotes (Fig. 1 A).

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