Poncirin Alleviates Hypoxic Pulmonary Hypertension by Blocking TDP43-Mediated Macrophage Pyroptosis.

Regardless of whether PASMCs were exposed to normoxic or hypoxic conditions, the number of EdU‐positive cells decreased (Figure 4K,L ; p < 0.01) and the protein levels of CDK4 and PCNA decreased (Figure 4M–O ; p < 0.05) after the addition of Poncirin, while the number of EdU‐positive PASMCs, the protein expression levels of CDK4 and PCNA showed an increasing trend after up‐regulation of TDP43. 3.5.

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