Helminth-derived stefin-1 selectively reduces leukemic cell viability and promotes apoptosis in U937 cells.

After treatment of the U937 cells with the r Fg Stefin-1 at 5.5 μM (0.5x IC 50 ), 11 μM (1x IC 50 ), and 22 μM (2x IC 50 ) for 48 hours, PI3K expression showed a decreasing trend across all concentrations; however, the difference was not statistically significant ( Fig 6B ).

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