The following procedure was applied to compare the negative control group (NC) and the group of pediatric participants with severe chronic multisystem underlying diaseses (ULD) by using the Mann-Whitney test for unpaired samples ( Figure 4 ), which resulted in a highly significant p-value of 0.0001 (**** in the figure).
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Phase-dependent dynamics of circulating cell-free mitochondrial DNA reflect distinct immunometabolic states.
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