Pathogenicity Classification of <i>TARDBP</i> Variants of Uncertain Significance: An Integrative Clinical Characterization and Functional Validation.

Cells · 2026 · PMC13407010 · PMID 42505342

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an increasing trendno p-value reported

Among them, the percentage of aggregate-positive cells for variants p.D23N, p.T32I, p.N70D and p.P363A showed an increasing trend but did not reach statistical significance; the percentage of aggregate-positive cells for the p.N76S variant appeared to decrease, which also did not reach statistical significance.

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Pathogenicity Classification of &lt;i&gt;TARDBP&lt;/i&gt; Variants of Uncertain Significance: An Integrative Clinical Characterization and Functional Validation.

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Pathogenicity Classification of <i>TARDBP</i> Variants of Uncertain Significance: An Integrative Clinical Characterization and Functional Validation.