From an immunological perspective, this efficacy in ICI-refractory tumors is highly significant; it demonstrates that EV can effectively target and eradicate tumor clones that have developed adaptive immune resistance and successfully evaded T-cell-mediated clearance.
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Enfortumab Vedotin in Advanced or Metastatic Urothelial Carcinoma: A Systematic Review of Efficacy, Safety, and Clinical Perspectives.
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