highly significantp < 0.001
For CK, the linear time effect remained highly significant on the log1p scale ( p < 0.001 ); for ESR, the linear time effect weakened from p = 0.030 on the raw scale to p = 0.099 on the log1p scale, consistent with modest skew-induced inflation in the raw analysis, while the absence of condition and condition-by-time effects was preserved.