highly significantp < 0.001
Two-way ANOVA revealed a nonsignificant main effect of treatment [ F (1, 12) = 3.273, p = 0.096, η 2 p = 0.214], a highly significant main effect of time [ F (2, 12) = 359.273, p < 0.001, η 2 p = 0.984], and a significant treatment × time interaction effect [ F (2, 12) = 42.545, p < 0.001, η 2 p = 0.876] on CYP450 activity.