HLA-B class I allele associations with neurological complications in pediatric SARS-CoV-2 infection: a retrospective observational study.

BMC Pediatr · 2026 · PMC13412170 · PMID 42522012

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hedged sentences

0.0770

closest p · 1.5× alpha

0.0770

boldest claim

The sentences

a positive trendp = 0.077so close (0.05 < p ≤ 0.1)

However, in exploratory unadjusted analyses, HLA-B53 showed higher odds of neurological involvement when compared with children without neurological disease and healthy controls (OR = 6.29; 95% CI: 1.23–32.13; nominal p = 0.027), while HLA-B45 demonstrated a positive trend (OR = 3.75; 95% CI: 0.87–16.22; nominal p = 0.077).

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a possible trendno p-value reported

Such a mechanism could explain the increased susceptibility of HLA-B53 carriers to CNS-targeted inflammatory injury in COVID-19, whereas the lower observed frequency of HLA-B52 in the neuro-COVID group suggests a possible trend; however, it was not statistically significant.

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