Cathepsin B-Oriented Screening, Isolation, and Antitumor Validation of Bioactive Metabolites from <i>Sargassum polycystum</i>.

Inhibitory Effects of Active Compounds on Intracellular CTSB Activity The results showed that active compounds inhibited intracellular CTSB activity in NCI-H1975 cells to varying extents, with an overall trend of enhanced inhibition as the treatment concentration increased, indicating a relatively clear concentration-dependent inhibitory effect on CTSB.

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polycystum low-, middle-, and high-dose groups, Bax expression increased to 0.0055, 0.0078, and 0.0104, respectively, showing an increasing trend with dose escalation.

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