Single-cell profiling reveals immunometabolic remodeling with T-cell dysfunction in HIV-1 infected people.

Infect Dis Immun · 2026 · PMC13412707 · PMID 42524707

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a decreasing trendno p-value reported

Among these, the naive subset CD8-CCR7 was significantly reduced in TN patients compared to HD ( P < 0.05), whereas CD4-CCR7 showed a decreasing trend.

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an increasing trendno p-value reported

Conversely, the effector subset CD8 + activated effector/memory T cells (CD8-EMRA) were significantly increased in TN patients ( P < 0.05), while cytolytic CD4 + T cells (CD4-CTL) displayed an increasing trend.

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