Brain-Targeted 5-ALA-CAT Liposomes (BACL) Alleviate Hypoxia and Enhance Photodynamic Therapy in a Murine Glioblastoma Flank Xenograft Model via Angiopep-2-Mediated Targeting.

As demonstrated in Figure 5 E,H, the average apoptosis rates for the 5-ALA, AL, ACL, and BACL groups were 45.31%, 49.92%, 61.21%, and 76.86%, respectively, indicating an increasing trend in the proportion of GBM cells undergoing apoptosis.

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Both the particle size and PDI of the reconstituted formulation showed a decreasing trend with increasing trehalose concentration, indicating that a higher amount of trehalose enhances its lyoprotective effect and effectively maintains the stability of the lipid bilayer structure ( Table S2 ).

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