NLRP3 Inhibitor KBD3536 Attenuates Acute Inflammation, Radiation-Induced Skin Injury, and Early Metabolic Dysfunction in Preclinical Models.

Although statistical significance was not achieved—likely due to the limited sample size—KBD3536 exhibited a notable trend toward restricting the HFD-induced increase in adipocyte size ( Figure 5 D), as corroborated by representative H&E staining ( Figure 5 E).

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KBD3536 also showed a favorable trend compared with orlistat.

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