Barely Significant
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Backbone-Minimised Nanoplasmid DNA Systems Enable High-Titre AAV Production in Suspension HEK293 Platforms.

Pharmaceutics · 2026 · PMC13414656 · PMID 42514892

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highly significantp < 0.0001actually significant
The resulting quadratic model was statistically robust (R 2 = 0.874; adjusted R 2 = 0.845; p < 0.0001), with DNA:PEI ratio emerging as the dominant determinant of titre, supported by highly significant linear ( p < 0.0001) and quadratic ( p = 0.00028) terms.

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