Bisoprolol and Amlodipine Co-Administration with Glimepiride in a Diabetic Rat Model: A Statistical and Machine Learning Analysis.

Pharmaceuticals (Basel) · 2026 · PMC13415167 · PMID 42515745

Europe PMC DOI

hedged sentences

0.0000

closest p · 0.0× alpha

0.0040

boldest claim

The sentences

highly significantp < 10 −9actually significant

The Kruskal–Wallis test confirmed highly significant global heterogeneity (H = 94.31, p < 10 −9 ).

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a decreasing trendp = 0.004actually significant

Within the diabetic cohorts, glimepiride+bisoprolol alone had a decreasing trend (−0.66 percentage points from baseline to week 11; Wilcoxon p = 0.004) and was trending towards healthy levels.

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