Development and Evaluation of Physiologically Based Pharmacokinetic (PBPK) Models to Investigate the Effect of CYP2D6 Polymorphism on Metoclopramide Systemic Exposure.

Pharmaceuticals (Basel) · 2026 · PMC13415256 · PMID 42515786

Europe PMC DOI

hedged sentence

—

closest p

—

boldest claim

The sentences

an increasing trendno p-value reported

Moreover, an increasing trend in AUC 0–∞ was observed across CYP2D6*wt/*wt , CYP2D6*wt/*10 , CYP2D6*10/*10 , and CYP2D6*5/*10 , with approximately 1.63-, 2.64-, and 2.88-fold increases compared with the CYP2D6*wt/*wt genotype.

also in 63,971 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.