Transcriptional evidence of neuroendocrine cell plasticity beyond histological boundaries in lung neuroendocrine neoplasms: an in-silico analysis suggesting a progression model.

Multivariate Cox survival analysis confirmed the independent prognostic significance of the PNEN-B versus PNEN-A subgroup classification in carcinoids (HR, 5.86; p = 0.009), while a trend toward significance was observed in SCLC (HR, 1.59; p = 0.09), but not in LCNEC (Table 1 ).

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