Evaluation of Immunogenicity and Cross-Protective Efficacy of a CpG-Adjuvanted Trivalent Inactivated Influenza Vaccine in Ferrets.

Additionally, there were differences in the immune induction efficacy of the vaccine on the three viruses, with an overall trend of BV > H3N2 > H1N1 (GMT values on Day 42 in the high-dose group: BV 60703 > H3N2 50564 > H1N1 11682).

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For the challenge model of H3N2 A/Hong Kong/4801/2014 strain, compared with the model group, there was no significant difference in the viral load in the nasal wash fluid of the commercial vaccine group at different time points; the viral load in the nasal wash fluid of the low-dose group of the test trivalent vaccine showed a decreasing trend on Day 1, Day 3, and Day 5, among which there was a statistically significant difference in the reduction of viral load on Day 1 ( p < 0.05); the viral load in the nasal wash fluid of the high-dose group of the test trivalent vaccine was significantly reduced on Day 1, Day 3, and Day 5 ( p < 0.05).

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