Moderate intensity aerobic exercise alleviates motor deficits in 6-OHDA lesioned rats and reduces serum levels of biomarkers of Parkinson's disease severity without recovery of striatal dopamine or tyrosine hydroxylase.

Locomotor function during nigrostriatal lesion progression Prior to random assignment into NE or EX groups, reduced forelimb use was confirmed in 6-OHDA lesioned rats on day 7 (1 wk) post-lesion (F (1,29) = 64.6, p < 0.0001), with highly significant difference between sham and lesion groups (Sham, 105.7 ± 2.6%; 6-OHDA, 46 ± 4.3%) (F (1,31) = 97.8, p < 0.0001), but not between rats assigned to NE or EX groups prior to initiating exercise (F (1,31) = 0.13, p = 0.72) ( Fig. 3A ).

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