Synergistic Value of Combined Electrical, Structural, and Functional Response Metrics in the Prediction of Long-Term Event-Free Survival After Cardiac Resynchronization Therapy.

Crucially, our multivariate regression model demonstrated that a composite favorable response—defined by concurrent achievement of QRS narrowing ≥20 ms, LVESV reduction ≥15%, and LVEF improvement ≥10% at 6–12 months—was a highly significant predictor of event-free survival (Overall model p = 0.006).

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