Immune checkpoint crosstalk: CTLA-4/CD80 engagement as a predictor of anti-PD-1/PD-L1 therapy outcome in NSCLC.

Front Immunol · 2026 · PMC13422567 · PMID 42535087

Europe PMC DOI

hedged sentences

0.0800

closest p · 1.6× alpha

0.0800

boldest claim

The sentences

a favorable trendP = 0.08so close (0.05 < p ≤ 0.1)

A favorable trend in PFS was also observed (P = 0.08; HR = 0.62, 95% CI: 0.36–1.07) ( Supplementary Figure 2A ).

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highly significantno p-value reported

There was found to be a correlation between PD-1/PD-L1 high and CTLA-4/CD80 high engaged patients, which translated into the finding that combined double high readouts were highly significant predictors of response to ICI treatments.

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