Although their results did not reach statistical significance, they demonstrated a favorable trend toward stroke reduction ( Hagag et al., 2025 ). 7.
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Colchicine in atrial fibrillation: mechanisms, highlights, and current evidence.
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In a comparative study using a rat model of sterile pericarditis to investigate the efficacy of amiodarone, colchicine, and extracellular vesicles (EVs) derived from human cardiac cells in preventing POAF, colchicine demonstrated a positive trend toward reducing the incidence of POAF, although this trend was not statistically significant ( Parent et al., 2024 ).