highly significantp < 0.001
Previously reported data demonstrated a pronounced TP53-dependent differential response of HL cell lines to etoposide treatment: TP53-wildtype L-540 cells responded faster and more robustly than TP53-mutant L-428 cells with respect to reduced proliferation and viability, induction of apoptosis and necrosis (absent in L-428), accelerated nuclear fragmentation, and highly significant differential expression of apoptosis-related genes ( p < 0.001), including TP53, TNFα, HO1, and GADD45.