highly significantp < 0.0001
Longitudinal tumor growth data, analyzed using a linear mixed-effects model with restricted maximum likelihood, revealed highly significant effects for both the time × group interaction [ p < 0.0001, F(5.514, 32.81) = 11.36] and the group main effect [ p < 0.0001, F(5, 119) = 41.56] ( Figure 2e ).